Développement d'outils biophysiques originaux pour évaluer l'effet combiné des polluants et des virus sur des tissus pulmonaires modèles

Development of original biophysical tools to evaluate the combined effect of pollutants and viruses on model lung tissue

• Auteur / Autrice : Iyad Abou shakra
• Direction : Gladys Massiera
• Type : Projet de thèse
• Discipline(s) : Physique et Astrophysique
• Date : Inscription en doctorat le 01/10/2024
• Etablissement(s) : Université de Montpellier (2022-....)
• Ecole(s) doctorale(s) : École Doctorale Information, Structures, Systèmes
• Partenaire(s) de recherche : Laboratoire : L2C - Laboratoire Charles Coulomb
• Partenaire(s) de recherche : Equipe de recherche : Axe de Recherche Matière Molle et Verres

Mots clés

Mots clés libres

Microfluidique

Matière molle

Matière active

Biophysique

Fonction mucociliaire

Exposome

Exposome

Biophysics

Soft Matter

Mucociliary function

Microfluidics

Active Matter

Résumé

Development of original biophysical tools to assess the combined effect of pollutants and viruses on model lung tissues We are offering a PhD position in experimental biophysics from October-November 2024, in the SoftMatter-Charles Coulomb Laboratory, University of Montpellier team. The COCKTAIL project aims to develop an advanced 'bronchus-on-a-chip' model, called iOC, based on microfluidic technology, which will enable the precise and quantitative application of various pollutants, alone or in combination with viral infections. Using microfluidics and high-throughput imaging, the candidate will study the physics of ciliary beating and mucus flow in a microfluidic chamber model of the pulmonary bronchus, and by participating in a larger project, with experts in virology and airway organoid biology.

Building original biophysical tools to evaluate the combined effects of pollutants and viruses on model lung tissues Applications are invited for a PhD position in experimental biophysics starting in October-November 2024, in the SoftMatter team-Laboratoire Charles Coulomb, University of Montpellier. The COCKTAIL project aims to develop an advanced 'airway on a chip' model, called iOC, based on microfluidics technology, which will allow for the precise and quantitative application of various pollutants, either alone or in combination with viral infections. Using microfluidics and high-speed imaging, the candidate will investigate the physics of cilia beating and mucus flow on a mini-lung chamber, taking part to a larger project, with virologists and experts of airway organoids.