Thermal wavefront shaping, towards adaptive endoscopy

• Auteur / Autrice : Hasan Sawan
• Direction : Gilles Tessier
• Type : Projet de thèse
• Discipline(s) : Physique
• Date : Inscription en doctorat le 01/03/2024
• Etablissement(s) : Sorbonne université
• Ecole(s) doctorale(s) : École doctorale Physique en Île-de-France (Paris ; 2014-....)
• Partenaire(s) de recherche : Laboratoire : Institut de la Vision

Mots clés

Mots clés libres

Wavefront shaping

Optogenetics

Deep learning

Endoscopy

Résumé

The advent of spatial control over the phase of light waves, also called wavefront shaping, has deeply transformed photonics, enabling major advances in microscopy. This is particularly true in the field of Neurophotonics, a major research interest at Institut de la Vision, which aims at controlling and reading out neuronal activity with light (using optogenetics or calcium/voltage indicators). To be most relevant, neuron imaging and photostimulation must essentially move away from static laboratory microscopes to study the brain of fully awake, freely moving animals able to perform behavioural tasks. This can be accomplished today by using low weight and flexible optical fiber-based endoscopes. Beyond millimetre-range depths, endoscopy is arguably the only existing imaging solution, although it is affected by strong aberrations, and is only able to image a fixed z-plane. Within the Photonics Department of Institut de la Vision, this PhD project brings together the “3D microscopy” team, which specializes in wavefront manipulation and imaging, and the “Fiber Optogenetics” team, which develops structured illumination and endoscopic systems for optogenetics.