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Analyses radiomique et anthropométrique en imagerie multimodale pour l'exploration de facteurs prédictifs et pronostiques en oncologie.

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Auteur / Autrice : Pierre Decazes
Direction : Pierre Vera, Isabelle Gardin
Type : Thèse de doctorat
Discipline(s) : Sciences de la vie et de la sante
Date : Soutenance le 03/12/2021
Etablissement(s) : Normandie
Ecole(s) doctorale(s) : École doctorale Normande de biologie intégrative, santé, environnement (Mont-Saint-Aignan, Seine-Maritime)
Partenaire(s) de recherche : établissement de préparation : Université de Rouen Normandie (1966-....)
Laboratoire : Laboratoire d'informatique, de traitement de l'information et des systèmes (Saint-Etienne du Rouvray, Seine-Maritime ; 2006-...)
Jury : Président / Présidente : Françoise Kraeber-Bodéré
Examinateurs / Examinatrices : Pierre Vera, Isabelle Gardin, Françoise Kraeber-Bodéré, Olivier Humbert
Rapporteur / Rapporteuse : Jean-Emmanuel Bibault, Aurélie Kas

Résumé

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Personalized medicine refers to the adaptation of medical treatment to the individual characteristics of each diseaseand each patient. In oncology, this adaptation depends in particular on the prognosis of the disease in order to adapt a treatmentto the severity of the cancer. Medical imaging, represented in particular by the CT scan and the PET scan, allows the extraction andanalysis of morphological and functional characteristics of the cancer, called ''radiomics'', but also of the patient's characteristics,called ''anthropometrics''. The objective of this work was to explore the use of radiomic and anthropometric parameters inmultimodal imaging for the exploration of prognostic factors in oncology.For the anthropometric side, we developed and evaluated a software, named ''Anthropometer3D'', allowing themeasurement of muscle, lean, fat, visceral adipose tissue and subcutaneous adipose tissue masses in a multi-slice and automaticway from PET/CT scans and showed the prognostic value of subcutaneous adipose tissue for stage IV lung cancers treated withimmunotherapy and of muscle mass for lung cancers treated with radio-chemotherapyFor the radiomic side, we have developed and evaluated algorithms for the automatic segmentation and classification ofoncological PET/CT scans and developed a software, named ''Oncometer3D'', for the extraction of tumor activity, fragmentation,dispersion and massiveness characteristics from PET scans. We showed that one fragmentation parameter, the volume to totaltumor area ratio, was an independent prognostic factor in diffuse large-cell B-cell lymphoma and that several morphological tumorparameters correlated with circulating tumor DNA in B-cell hemopathies.In conclusion, medical imaging participates in the global evaluation of cancer from a macroscopic point of view byallowing a radiomic analysis centered on the tumor but also anthropometrically centered on the patient. Improved prognosticationusing these two approaches could lead to better therapeutic management of patients.