This memoir contributes to solve the equivalence problem for CR-manifolds in dimension up to 5. We first deal with the equivalence problem for 5-dimensional CR-manifolds which are 2-nondegenerate and of constant Levi rank 1. For such a manifold M, we find two invariants, J and W, the annulation of which gives a necessary and sufficient condition for M to be locally CR-equivalent to a model hypersurface, the tube over the light cone. If one of the invariants does not vanish on M, we construct an absolute parallelism on M, that is we show that the equivalence problem reduces to an equivalence problem between 5-dimensional {e}-structures. We then study the equivalence problem for 4-dimensional CR-manifolds which are known as Engel manifolds. This problem is solved by the construction of a canonical Cartan connection on a 5-dimensional bundle through Cartan's equivalence method. We also study the equivalence problem for 5-dimensional CR-manifolds whose CR-bundle satisfies a certain degeneracy assumption, and show that in this case, the problem is solved by the construction of a Cartan connection on a 6-dimensional bundle. The last part of this memoir is devoted to the determination of the Lie algebra of infinitesimal automorphisms for the model manifolds of the three previous classes.