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Efflux et Homéostasie intracellulaire du Cholestérol : Impact de l'hypertriglycéridémie, de l'obésité et/ou de l'insulinorésistance et des Acides Gras de type trans
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| Auteur / Autrice : | Nesrine Attia Skhiri |
| Direction : | Jean-Louis Paul |
| Type : | Thèse de doctorat |
| Discipline(s) : | Biochimie |
| Date : | Soutenance en 2009 |
| Etablissement(s) : | Paris 11 |
Mots clés
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Résumé
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Scavenger Receptor BI (SR-BI), ATP Binding Cassette Transporter (ABCA1) and ATP Binding Cassette Transporter (ABCG1) expressed at the cellular level, regulate the cholesterol efflux and intracellular homeostasis. Our Study of acceptors (hypertriglyceridemic patients serums) then donors (cells in culture) allowed to demonstrate that certain factors could modify the circulating concentrations of specific acceptors ( pré-b HDL) but also, the feature of these carriers with for consequences in both cases variations of the efflux of the cholesterol.