Effets de l'hypoxie chronique et du monoxyde de carbone sur la fonction cardiaque et l'activité des canaux potassiques des cellules musculaires lisses d'artères coronaires chez le rat

Effects of chronic hypoxia and carbon monoxide on cardiac function and potassium channels in rat coronary artery smooth muscle cells

• Auteur / Autrice : Mathieu Gautier
• Direction : Pierre Bonnet
• Type : Thèse de doctorat
• Discipline(s) : Sciences de la vie et de la santé
• Date : Soutenance en 2005
• Etablissement(s) : Tours

Mots clés

Mots clés contrôlés

Appareil cardiovasculaire

Anoxie

Pollution atmosphérique

Résistance à la pollution atmosphérique

Animaux

Effets de la pollution atmosphérique

Rats de laboratoire

Circulation coronaire

Myocytes

Résumé

This work shows that low doses of carbon monoxyde (CO) corresponding to air pollution impair right ventricle (RV) and right coronary circulation adaptive response in animals preexposed to hypoxic hypoxemia. A complementary study on coronary smooth muscle cell shows that voltage-gated potassium channels contribute to the repolarizing outward membrane currents and they were impaired following hypoxemia and CO exposures. This work provides physiological findings on the cardiac effects of air pollution and increased sensitivity in hypoxic hypoxemic animals. We have used the techniques of cardiovascular functional exploration and electrophysiological assessment of the coronary smooth muscle cell.