Préconditionnement et postconditionnement myocardiques induits par les agents anesthésiques halogénés
Auteur / Autrice : | Pascal Chiari |
Direction : | Jean-Jacques Lehot |
Type : | Thèse de doctorat |
Discipline(s) : | Physiologie cardio-vasculaire |
Date : | Soutenance en 2005 |
Etablissement(s) : | Lyon 1 |
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Résumé
Volatile anesthetics protect myocardium against reversible and irreversible ischemic injury. Using a rabbit in vivo model, we compared the potency of four different halogenated to induce preconditioning. We shown that brain death induced catecholamines storm retains the ability to protect the heart by isoflurane inhalation. A new emulsified formulation of halogenated administered intravenously induces acute and delayed preconditioning. Mitochondrial adenosine triphosphate-sensitive potassium channels and mechanogated channels are involved in halogenated-induced acute preconditioning. Desflurane-induced preconditioning improved the resistance of the mitochondrial permeability transition pore to calcium-induced opening. Endothelial nitric oxide synthase is a trigger and mediator of delayed preconditioning by isoflurane. Isoflurane acts during early reperfusion by activation of the phosphatidylinositol-3-kinase signalling