Synthese de derives phenoliques et etude de leur proprietes hypopigmentantes

Synthesis and hypopigmenting properties of some phenolic compounds

• Auteur / Autrice : Christian Wasser
• Direction : Claude Benezra
• Type : Thèse de doctorat
• Discipline(s) : Chimie
• Date : Soutenance en 1987
• Etablissement(s) : Université Louis Pasteur (Strasbourg) (1971-2008)

Mots clés

Mots clés libres

Chimie

Chimie organique

Rodentia

Mammalia

Vertebrata

Ether

Diphenols

Compose sature

Depigmentation

Activite biologique

In vivo

In vitro

Cobaye

Essai

Animal

Hydroxyacide

Hydroxyether

Compose aliphatique

Compose acetylenique

Compose bicyclique

Compose aromatique

Heterocycle azote

Phenol(alkyl-2 methoxy-4)|fin

Phenol(alcoxy-4)|fin

Phenol(alkyl-3 methoxy-4)|fin

Tyrosine analogue

Benzenepropionique acide(hydroxy-4 alpha -methyl)|fin

Isoquinoleinecarboxylique-3 acide(hydroxy-7 tetrahydro-1,2,3,4)|fin

Benzenepropiolique acide(hydroxy-4)

Phenol(acyl-2 methoxy-4)|fin

Tyrosinase

Rodentia

Mammalia

Vertebrata

Ether

Diphenols

Saturated compound

Hypomelanosis

Biological activity

In vivo

In vitro

Guinea pig

Test

Animal

Hydroxyacid

Hydroxyether

Aliphatic compound

Acetylenic compound

Bicyclic compound

Aromatic compound

Nitrogen heterocycle

Résumé

Ce memoire presente les syntheses d'acyl-2 methoxy-4 phenols (a) d'alkyl-2 methoxy-4 phenols (b), d'alkyl-3 methoxy -4phenols (c), d'alkoxy-4 phenols (d) d'acide (hydroxy-4' phenyl)-3 methyl-2 propionique (e), d'acide (hydroxy-4' phenyl)-3 hydroxy-2 propionique, d'hydroxy-7 carboxy-3 tetrahydro-1,2,3,4 isoquinoleine et d'acide hydroxy-4 phenylpropargylique(f). L'etude ''in vivo'' (cobayes) et ''in vitro'' des proprietes hypopigmentantes des composes a, b, c, d, e et f. L'etude ''in vivo'' et ''in vitro'' des proprietes hypopigmentantes de substances naturelles : arbutine, luteoline, abscissine