Etude de la structure et fonction du ribosome par des méthodes computationnelles

Structure and function of the ribosome from molecular simulations

• Auteur / Autrice : Paula Mihaljevic-juric
• Direction : Thomas Simonson
• Type : Projet de thèse
• Discipline(s) : Biologie et Chimie
• Date : Inscription en doctorat le 01/10/2018
• Etablissement(s) : Institut polytechnique de Paris
• Ecole(s) doctorale(s) : École doctorale de l'Institut polytechnique de Paris
• Partenaire(s) de recherche : Laboratoire : BIOC - Laboratoire de Biologie Structurale de la Cellule

Mots clés

Mots clés libres

Ribosome

Traduction du code génétique

Cryo microscopie électronique

Simulations moléculaires

Ribosome

Genetic code translation

Cryo electron microscopy

Molecular simulations

Résumé

The research project will aim to understand the structure and function of the ribosome, using large-scale computer simulations and high resolution electron microscopy data obtained by collaborators within our department. It will focus specifically on the initiation steps of protein translation and the inhibitory role of antibiotics. Our group (http://biology.biocomputing.fr/biocomputing; https://orcid.org/0000-0002-5117-7338) develops and applies simulations methods to understand and engineer biomolecules. Ecole Polytechnique is highly-ranked internationally, with a small, interdisciplinary research campus just outside Paris, and is part of the much larger Paris-Saclay science cluster. Overall, the candidate will be trained in advanced biomolecular simulation methods, including advanced molecular dynamics simulations, as well as experimental methods to study large cellular complexes such as the ribosome.