Développement de nouveaux ligands polyaminés du fer pour la vectorisation anticancéreuse : synthèse, caractérisation et évaluation biologique
Auteur / Autrice : | Vincent Corcé |
Direction : | David Deniaud, François Gaboriau |
Type : | Thèse de doctorat |
Discipline(s) : | Chimie fine , Chimie organique |
Date : | Soutenance en 2012 |
Etablissement(s) : | Nantes |
Partenaire(s) de recherche : | autre partenaire : Université de Nantes. Faculté des sciences et des techniques |
Jury : | Président / Présidente : Clotilde Policar |
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Résumé
The aim of this work is the development of new and selective iron (III) chelators bearing polyamine moieties to target the PTS and to induce specifically an iron depletion into tumor cells. These hybrid molecules, named Quilamines, are based on the association of 8-hydroxyquinoline with different polyamine chains. Synthesis and biological studies of different polyamine moieties, analogues of spermidine and spermine, showed that the homospermidine chain was the best choice for an efficient vectorization. Biological analysis highlighted a great PTS selectivity and a promising antiproliferative activity for some Quilamines. Structural modifications of the ligands allowed to modulate the iron complexation properties and to increase the selectivity and efficiency. Finally, for one compound, potentiometric titrations showed a high iron affinity constant and a good selectivity toward other biological metals such as cooper and zinc.