Auteur / Autrice : | Stéphanie Coubard |
Direction : | Catherine Belzung, Pascal Barone |
Type : | Thèse de doctorat |
Discipline(s) : | Sciences de la vie |
Date : | Soutenance en 2004 |
Etablissement(s) : | Tours |
Mots clés
Mots clés contrôlés
Résumé
The neuropsychopharmacology of anxiety suggests the implication of the amygdala and the serotoninergic neurons in this pathology. Our purpose was to determine how the acute action of 5-HT1A receptors ligands is able to modulate anxiety in the mouse using 2 animal models of anxiety. More precisely we tried to determine if the effect of molecules results from a pre or postsynaptic action on the 5-HT1A receptors. We made intracerebral infusions of various 5-HT1A receptors ligands into the dorsal raphe (presynaptic receptors), and into the amygdala (postsynaptic receptors). We used are a partial agonist (buspirone), 2 full agonists ((+/-) and (+)-8-OH-DPAT) and an antagonist (WAY-100635). Our results show that infusions into the dorsal raphe produce an anxiolytic effect for all drugs. Into the amygdala, an anxiolytic effect is also obtained with the infusion of the 3 agonists but not with the antagonist.