Thèse soutenue

Contribution à l'étude du mode d'action de composés sérotoninergiques dans l'anxiolyse par microperfusion intracérébrale chez la souris : rôle des récepteurs 5-HT[1A] pré et postsynaptiques
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Accès à la thèse
Auteur / Autrice : Stéphanie Coubard
Direction : Catherine BelzungPascal Barone
Type : Thèse de doctorat
Discipline(s) : Sciences de la vie
Date : Soutenance en 2004
Etablissement(s) : Tours

Mots clés

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Résumé

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The neuropsychopharmacology of anxiety suggests the implication of the amygdala and the serotoninergic neurons in this pathology. Our purpose was to determine how the acute action of 5-HT1A receptors ligands is able to modulate anxiety in the mouse using 2 animal models of anxiety. More precisely we tried to determine if the effect of molecules results from a pre or postsynaptic action on the 5-HT1A receptors. We made intracerebral infusions of various 5-HT1A receptors ligands into the dorsal raphe (presynaptic receptors), and into the amygdala (postsynaptic receptors). We used are a partial agonist (buspirone), 2 full agonists ((+/-) and (+)-8-OH-DPAT) and an antagonist (WAY-100635). Our results show that infusions into the dorsal raphe produce an anxiolytic effect for all drugs. Into the amygdala, an anxiolytic effect is also obtained with the infusion of the 3 agonists but not with the antagonist.