Synthese, structure, proprietes physicochimiques et etude ''in vitro'' du pouvoir reactivateur de nouveaux antidotes de l'acetylcholinesterase inhibee par des organophosphores

Synthesis, structure, physicochemical properties and in vitro reactivity power study of new antidotes of acetylcholinesterase inhibited by organophosphorus compounds

• Auteur / Autrice : FRANCOISE DEGORRE CECCALDI
• Direction : Robert Schaal
• Type : Thèse de doctorat
• Discipline(s) : Chimie
• Date : Soutenance en 1988
• Etablissement(s) : Paris 6

Mots clés

Mots clés libres

Chimie

Chimie organique

Constante dissociation

Cetoaldehyde

Aldoxime

Nucleophilicite

Fonction broensted

In vitro

Acetylcholinesterase

Reactivation

Enzyme

Cetosulfure

Cetosulfone

Cetosulfoxyde

Propriete physicochimique

Phosphore compose organique

Compose aliphatique

Compose sature

Toxicite

Propanal(methylthio-13 oxo-2)oxime

Propanal(methanesulfinyl-3 oxo-2)oxime

Propanal(mesyl-3 oxo-2)oxime

Sulfonium(dimethyl hydroxyimino-3 acetonyl)

Dissociation constant

Ketoaldehyde

Aldoxime

Nucleophilicity

Broensted function

In vitro

Acetylcholinesterase

Reactivation

Enzyme

Ketosulfide

Oxosulfone

Ketosulfoxide

Physicochemical properties

Phosphorus organic compounds

Aliphatic compound

Saturated compound

Toxicity

Résumé

Synthese et etude de composes r-ch::(2)coch=noh (r=ch::(3)s; ch::(3)so; ch::(3)so::(2); (ch::(3))::(2)s**(+))